CENTERS FOR DISEASE CONTROL AND PREVENTION;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
BIRD BRIAN H,ALBARINO CESAR G,NICHOL STUART T,KSIAZEK THOMAS G
申请号：
ZA201004994
公开号：
ZA201004994B
申请日:
2010.07.14
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
