The United States of America as represented by the Secretary of the Department of Health and Human Services; Centers for Disease Control and Prevention
发明人:
Brian H. Bird,Cesar G. Albarino,Stuart T. Nichol,Thomas G. Ksiazek
申请号：
US14163058
公开号：
US09439935B2
申请日:
2014.01.24
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
