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Coating formulation
专利权人:
武田薬品工業株式会社
发明人:
坂東 博人,大町 佳宏,清島 健一郎
申请号:
JP2009522677
公开号:
JP5350240B2
申请日:
2008.07.10
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention provides a preparation containing pioglitazone or a salt thereof as an active ingredient, which shows high bioavailability of pioglitazone and less interindividual variation in blood drug concentration, as well as a preparation with suppressed color change during preservation. The preparation contains a core containing a pharmaceutically acceptable organic acid with water solubility at 20°C of not less than 10 mg/mL and pK a1 (a negative common logarithm of the first acid dissociation constant K a1 ) at 25°C of not more than 5, and a coating layer containing pioglitazone or a salt thereof. The coating layer may further contain mannitol or trehalose.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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