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COATED PREPARATION
专利权人:
发明人:
申请号:
EP08791071.7
公开号:
EP2172200B1
申请日:
2008.07.10
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention provides a preparation containing pioglitazone or a salt thereof as an active ingredient, which shows high bioavailability of pioglitazone and less interindividual variation in blood drug concentration, as well as a preparation with suppressed color change during preservation. The preparation contains a core containing a pharmaceutically acceptable organic acid with water solubility at 20°C of not less than 10 mg/mL and pKa1 (a negative common logarithm of the first acid dissociation constant Ka1) at 25°C of not more than 5, and a coating layer containing pioglitazone or a salt thereof. The coating layer may further contain mannitol or trehalose.
来源网站:
中国工程科技知识中心
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