FRANK JR. CHAVEZ,VICTOR J. CEE,ANTHONY B. REED,ADRIAN L. SMITH,NURIA A. TAMAYO,ANDREW TASKER,HUI WANG,BIN LING - WU,RYAN WURZ,ESSA HU HARRINGTON,BRADLEY J. HERBERICH,CLAIRE L. M. JACKSON,BRIAN ALAN LA
申请号：
ARP130100648
公开号：
AR093740A1
申请日:
2013.02.28
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Drug composition and use for cancer prevention and treatment. Claim 1: a compound of formula (1), wherein the G link is a simple link or a double link； it is specified that G is a simple link, if y is C = or C (r74919) 8322 or X is C = or c832222；Ring a is a ring, which, together with the two carbon atoms it adds, forms a phenyl ring or a 5-6 member heterocyclic ring； X is n, No. 74955；C = O, ch or ch8322；This is n, number 749595,C = O, cr7491 or C (r74919) 8322；R is an alternative to dicyclooxyamide, an alternative to ethylene oxide, an alternative to epoxidin, or a formula compound (2)；R¹ is H, halo, alkyl, amino, alkylamino, alkenylamino, haloalkylamino, alkylsulfonylalkylamino, aminocarbonylalkylamino, aminoalkylamino, hydroxyalkylamino, alkylsulfonylamino, carboxyalkylamino, alkoxycarbonylalkylamino, alkoxyalkylamino, alkoxycarbonylaminoalkylamino, alcoxialcoxialquilamino, alcoxialquilaminoalquilamino, alquilsulfonilalquilaminoalquilamino, cycloalkylamino substituted or unsubstituted, cycloalkylalkylamino substituted or substituted, substituted or unsubstituted arylamino, substituted or unsubstituted arylalkylamino, substituted or unsubstituted heterocyclylamino, substituted or unsubstituted heterocyclyl-alkyl C₁₋₆amino, guanidinyl, -CONHRᵇ,-NHC = ORᵇ,-Or 74955,-S (3DO) R-CORᶜ,a. Replaced or unsubstituted arilalquilo, replaced or unsubstituted arilalquilo, substituted or unsubstituted arilalquenilo, substituted or unsubstituted cymcquillo, substituted or unsubstituted non cymcquillo, substituted or unsubstituted non cymcquillo, or substituted or unsubstituted non cymcquillo； R2 is h, or halogen； r7491 is h, halogen, or halogen tar； Oxyhydrogen, asphalt, asphalt, tar, ammonia, rental, cyanogen, HC (= O) -,HC (3DNOH) -a. Carboxi, alcoxicarbio, or isocyclohexane replaced or not replaced； r7495es h, octyl, halotar, carbamate, oxygen tar, cyclopropyl replaced or not replaced, arilo replaced or not replaced, arilalquilo replaced or not replaced, or isocyclohexane rep
