LIM SE YOUNG,PARK SUNG HEE,SHIN RYOUNG AE,CHOI IN YOUNG,KWON SE CHANG
申请号：
IN6694DEN2014
公开号：
IN6694DEN2014A
申请日:
2014.08.08
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical composition for the prevention and treatment of non alcoholic fatty liver disease (NAFLD) including a conjugate prepared by covalently linking an insulinotropic peptide a non peptidyl polymer and an immunoglobulin Fc region. The composition of the present invention maintains the in vivo activity of the peptide at a relatively high level and remarkably increases the blood half life thereby preventing triglyceride accumulation which is a typical feature of non alcoholic fatty liver disease. Ultimately it can be desirably employed for the prevention and treatment of non alcoholic fatty liver disease.
