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1H-BENZIMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
PFAU, ROLAND,ARNDT, KIRSTEN,DOODS, HENRI,HAUEL, NORBERT,KLINDER, KLAUS,KUELZER, RAIMUND,MACK, JUERGEN,PRIEPKE, HENNING,STENKAMP, DIRK
申请号:
NZ59184309
公开号:
NZ591843A
申请日:
2009.09.25
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
There are provided compounds of formula (I) and their use, wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer. Examples of diseases treated: asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, inflammatory bowel disease, irritable bowel syndrome, pain, inflammatory pain, fever, migraine, headache, low back pain, fibromyalgia, a myofascial disorder, a viral infection, a bacterial infection, a fungal infection, dysmenorrhea, a burn, a surgical or dental procedure, a malignancy, hyperprostaglandin E syndrome, classic Bartter syndrome, atherosclerosis, gout, arthritis, osteoarthritis, juvenile arthritis, rheumatoid arthritis, rheumatic fever, ankylosing spondylitis, Hodgkins disease, systemic lupus erythematosus, vasculitis, pancreatitis, nephritis, bursitis, conjunctivitis, iritis, scleritis, uveitis, wound healing, dermatitis, eczema, psoriasis, stroke, diabetes mellitus, a neurodegenerative disorder, an autoimmune disease, an allergic disorder, rhinitis, an ulcer, coronary heart disease, sarcoidosis, any other disease with an inflammatory component, osteoporosis, osteoarthritis, Pagets disease, a periodontal disease or a cancer. Examples of compounds of formula (I) include: 2-(6-Chloro-2-fluoro-3-methyl-phenylamino)-6-methoxy-N-(trans-4-trifluoromethyl-cyclohex-1-yl)-1-methyl-1H-benzimidazole-5-carboxamide, 2-(3,6-Dichloro-2-fluoro-phenylamino)-6-isopropoxy-N-(spiro[2.5]oct-6-yl)-1-methyl-1H-benzimidazole-5-carboxamide, 2-(6-Chloro-2-fluoro-3-methyl-phenylamino)-N-cyclohexyl-6-fluoro-1H-benzimidazole-5-carboxamide, 2-(6-Chloro-2-fluoro-3-methyl-phenylamino)-6-methoxy-N-(4,4-dimethyl-cyclohex-1-yl)-1-methyl-1H-benzimidazole-5-carboxamide, 2-(6-Chloro-2-fluoro-3-
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