UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
发明人:
AHN, KWANG SEOK,안광석
申请号：
KR1020110113169
公开号：
KR1020130048357A
申请日:
2011.11.02
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A composition containing a Patrinia scabiosaefolia extract for preventing and treating inflammatory diseases is provided to suppress NF-kappa B signal transduction.CONSTITUTION: A composition for preventing or treating inflammatory diseases contains a Patrinia scabiosaefolia extract as an active ingredient. The inflammatory diseases are selected from a group consisting of asthma, allergic and non-allergic rhinitis, chronic and acute rhinitis, chronic and acute gastritis or enteritis, ulcerative gastritis, acute and chronic nephritis, acute and chronic hepatitis, chronic obstructive pulmonary disease, fibroid lung, irritable bowel syndrome, inflammatory pain, migraine, lumbago, headache, fibromyalgia, viral infection(such as hepatitis type C), bacterial infection, fungal infection, burn, wound after surgical or dental operation, atherosclerosis, arthritis, rheumatoid arthritis, ankylosing spondylitis, Hodgkin disease, pancreatitis, conjunctivitis, iritis, scleritis, uveitis, dermatitis, and eczema. The extract is prepared using methanol, ethanol, acetone, ethyl acetate, butanol, chloroform, methylene chloride, water, or a mixture thereof.COPYRIGHT KIPO 2013본 발명은 패장(Patriniascabiosaefolia) 추출물을 유효성분으로 포함하는 염증성 질환(inflammatory disease)의 예방 및 치료용 조성물에 관한 것이다. 본 발명의 패장 추출물은 지질다당체(Lipopolysaccharide)에 의해 유도되는 산화질소(NO)의 생성 및 IL-6 분비를 억제하고, 지질다당체에 의해 유도되는 iNOS와 COX 단백질 및 이들의 mRNA의 발현을 억제하는 활성을 나타내며, NF-κB 신호전달 과정을 억제함으로써 결과적으로 염증성 질환의 예방 및 치료에 뛰어난 효과를 나타낸다.
