MITCHELL, LORNA HELEN,BELL, ANDREW SIMON,CHESWORTH, RICHARD,FOLEY, MEGAN ALENE CLOONAN,KUNTZ, KEVIN WAYNE,MILLS, JAMES EDWARD JOHN,MUNCHHOF, MICHAEL JOHN
申请号：
CA2960280
公开号：
CA2960280A1
申请日:
2015.09.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
