The invention relates to novel substituted tetrahydro-4H-thieno-pyrrolo[3,2-c]pyridines of general formula 1, geometric isomers thereof, mixtures of the geometric isomers thereof, and pharmaceutically acceptable salts thereof, where Th is an annulated thiene ring； W is a single bond (in this case R3 is bonded directly to the nitrogen atom of the pyrrole ring), a methylene, 1,2-ethane, 1,2-ethylene, 1,2-acetylene, 1,3-propane or 1,3-allyl bridge optionally substituted by a hydroxyl group； R1 and R2 are hydrogen, C
