WILLIAM J. GREENLEE,YUSHENG WU,LINGYAN WANG,ANDREW STAMFORD,ZHAONING ZHU,KURT W. SAIONZ,BRIAN MCKITTRICK,ZHONG-YUE SUN,YUANZAN C. YE,COREY STRICKLAND,ELIZABETH M. SMITH,ULRICH ISERLOH,ROBERT MAZZOLA,J
申请号：
PT04813947
公开号：
PT1699455E
申请日:
2004.12.13
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
Compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.
