Andrew Stamford;William J. Greenlee;Yuanzan C. Ye;Robert D. Mazzola;Brian McKittrick;John P. Caldwell;Zhaoning Zhu;Johannes H. Voight;Corey O. Strickland;Elizabeth M. Smith;Zhong-Yue Sun;Jared N. Cumm
发明人:
Zhaoning Zhu,Brian McKittrick,Zhong-Yue Sun,Yuanzan C. Ye,Johannes H. Voight,Corey O. Strickland,Elizabeth M. Smith,Andrew Stamford,William J. Greenlee,Robert D. Mazzola,John P. Caldwell,Jared N. Cumm
申请号：
US13420007
公开号：
US20120276118A1
申请日:
2012.03.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification； and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
