ZHU ZHAONING,ZHU Zhaoning,MCKITTRICK BRIAN,MCKITTRICK Brian,SUN ZHONG-YUE,SUN Zhong-Yue,YE YUANZAN C.,YE Yuanzan C.,STRICKLAND COREY,STRICKLAND Corey,SMITH ELIZABETH M.,SMITH Elizabeth M.,STAMFORD AND
申请号：
SI200432060
公开号：
SI1699455T1
申请日:
2004.12.13
申请国别(地区):
SI
年份:
2013
代理人:
摘要：
Compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.
