REPLACING NON-HUMAN ANIMALS TO CREATE CHIMERARY ANTIBODIES

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专利权人:

Ablexis; LLC

发明人:

GREEN, Larry,SHIZUYA, Hiroaki

申请号：

DK11763476

公开号：

DK2553100T3

申请日:

2011.03.31

申请国别(地区):

DK

年份:

2017

代理人:

摘要：

The invention provides A mouse whose genome comprises a transgene comprising a polynucleotide sequence comprising DNA sequences corresponding to DNA sequences from a mouse immunoglobulin locus except for polynucleotide sequences encoding one or more human immunoglobulin light chain variable (V) polypeptide sequences and one or more human immunoglobulin light chain joining (J) polypeptide sequences, wherein the sequences encoding the one or more human light chain V polypeptide sequences and the one or more human light chain J polypeptide sequences replace one or more mouse immunoglobulin light chain V coding sequences and one or more mouse immunoglobulin light chain J coding sequences, respectively.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/