MURPHY, Andrew J.,MACDONALD, Lynn,GUO, Chunguang,MCWHIRTER, John
申请号：
SG11202003044S
公开号：
SG11202003044SA
申请日:
2018.12.04
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
Non-human animals (and/or non-human cells) and methods of using the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain immunoglobulin (Ig) light chains characterized by the presence of human Vλ domains. Non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Vλ light chains that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igκ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided, which antibodies contain human variable regions and mouse constant regions.
