MURPHY, ANDREW J.,MACDONALD, LYNN,GUO, CHUNGUANG,MCWHIRTER, JOHN
申请号：
CA3084049
公开号：
CA3084049A1
申请日:
2018.12.04
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Non-human animals (and/or non-human cells) and methods of using the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain immunoglobulin (Ig) light chains characterized by the presence of human V? domains. Non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human V? light chains that are encoded by human Ig? light chain-encoding sequences inserted into an endogenous Ig? light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided, which antibodies contain human variable regions and mouse constant regions.
