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Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof
专利权人:
Inc.;Regeneron Pharmaceuticals
发明人:
MURPHY, Andrew J.,MACDONALD, Lynn,GUO, Chunguang,MCWHIRTER, John
申请号:
AU2018381316
公开号:
AU2018381316A1
申请日:
2018.12.04
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
Non-human animals (and/or non-human cells) and methods of using the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain immunoglobulin (Ig) light chains characterized by the presence of human Vλ domains. Non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Vλ light chains that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igκ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided, which antibodies contain human variable regions and mouse constant regions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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