Ulrich von Andrian;Elliott Ashley Moseman;Robert S. Langer;Omid C. Farokhzad;Pamela Basto;Jinjun Shi;Frank Alexis;Matteo Iannacone;Elena Tonti
发明人:
Frank Alexis,Matteo Iannacone,Jinjun Shi,Pamela Basto,Elliott Ashley Moseman,Ulrich von Andrian,Robert S. Langer,Omid C. Farokhzad,Elena Tonti
申请号：
US12428395
公开号：
US08343498B2
申请日:
2009.04.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
