MASSACHUSETTS INSTITUTE OF TECHNOLOGY;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人:
ELENA TONTI,ELLIOTT ASHLEY MOSEMAN,FRANK ALEXIS,JINJUN SHI,MATTEO IANNACONE,OMID C. FAROKHZAD,PAMELA BASTO,ROBERT LANGER,ULRICH VON ANDRIAN
申请号：
BRPI0920284
公开号：
BRPI0920284A2
申请日:
2009.10.09
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
