Massachusetts Institute of Technology;President and Fellows of Harvard College;The Brigham and Women's Hospital, Inc.
发明人:
Frank Alexis,Matteo Iannacone,Jinjun Shi,Pamela Basto,Elliott Ashley Moseman,Ulrich von Andrian,Robert S. Langer,Omid C. Farokhzad,Elena Tonti
申请号：
US14084424
公开号：
US20140127301A1
申请日:
2013.11.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
