KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION;YONG YANG GUN;고려대학교 산학협력단;영양군
发明人:
CHO, HONG YON,조홍연,HWANG, HAN JOON,황한준,LIM, WON CHUL,임원철,LEE, HEE SUB,이희섭,KIM, JONG HEON,김종헌,KWON, YOUNG TAEK,권영택,CHO, HONG YONKR,HWANG, HAN JOONKR,LIM, WON CHULKR,LEE, HEE SUBKR,KIM, JONG HEONKR,KWON, YOUNG TAEKKR
申请号：
KR1020120155979
公开号：
KR1020140086005A
申请日:
2012.12.28
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a composition for preventing, ameliorating, and treating obesity. The composition containing an extract of Ligularia fischeri Turez. as an active ingredient exhibits an excellent activity in inhibiting cell differentiation of 3T3-L1 fat precursor cells and a high inhibitory activity on the expression of PPAR-&gamma；, CEBP-&alpha；, and aP2 genes as upstream transcription factors in association with fat cell differentiation, and shows an excellent effect of inhibiting fat accumulation, thereby effectively preventing, ameliorating, and treating obesity. Further, the composition is a natural material, thus has a very high level of safety for the human body.본 발명은 비만의 예방, 개선 및 치료용 조성물에 관한 것이다.본 발명에 따른 곰취 추출물을 유효성분으로 포함하는 조성물은 우수한 3T3-L1 지방전구세포주의 세포분화 억제활성과 지방세포 분화와 관련하여 상위 전사인자인 PPAR-γ, CEBP-α, aP2 유전자 발현의 높은 저해를 보이며, 지방 축적 억제에 우수한 효과를 나타내어 효과적으로 비만을 예방, 개선 및 치료할 뿐만 아니라 천연소재로서 인체 안전성 또한 매우 높다.
