University of Pittsburgh—Of the Commonwealth System of Higher Education;MUSC Foundation for Research Development
发明人:
Wipf Peter,Feghali-Bostwick Carol A.
申请号：
US201615293107
公开号：
US9676738(B2)
申请日:
2016.10.13
申请国别(地区):
美国
年份:
2017
代理人:
Klarquist Sparkman, LLP
摘要：
A compound, or a pharmaceutically acceptable salt thereof, having a structure of;wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl;X is —S—, —S(O)—, or S(O)2—;R20 and R21 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, or halogenated alkyl;one of R22, R23, and R24 is —O— and the others of R22, R23 and R24 are independently —CH2—, or —C(R13)— wherein R13 is alkyl, alkenyl, alkynyl, trialkylsilyl group, or —(CH2)mOR15, wherein R15 is alkyl or an aryl and m is an integer in the range of 1 to 10; andR25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.
