BIALY, Laurent,LORENZ, Katrin,WIRTH, Klaus,STEINMEYER, Klaus,HESSLER, Gerhard
申请号：
ES13702225
公开号：
ES2623167T3
申请日:
2013.02.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a pharmaceutically acceptable salt thereof, ** Formula ** wherein n is selected from the series consisting of 0 and 1 ； m is selected from the series consisting of 0, 1 and 2, with the proviso that m and n cannot simultaneously be 0； X is selected from the series consisting of oxygen, sulfur and (R10) (R11) C； one of the groups R1 and R2 is the group R20-NH- and the other of the groups R1 and R2 is the group (R30) (R31) N-； R3 is selected from the series consisting of hydrogen, halogen and (C1-C4) alkyl； R4, R5, R6, R7, R8, R9, R10 and R11 are independently selected from each other from the series consisting of hydrogen, fluorine and (C1-C4) -alkyl； R20 is selected from the series consisting of cycloalkyl (C5-C7) to which a benzene ring or a Het1 ring is condensed, and (R21) (R22) (R23) C-, wherein the cycloalkyl (C5-C7) does not is substituted or substituted with one or more identical or different substituents selected from the series consisting of fluorine, (C1-C4) alkyl and (C1-C4) alkyl -O-, and the benzene ring and the condensed Het1 ring is not substituted or substituted with one or more identical or different R24 substituents； R21 is selected from the series consisting of phenyl and Het1, wherein phenyl and Het1 are not substituted or substituted with one or more identical or different R24 substituents； R22 is selected from the series consisting of hydrogen, (C1-C4) alkyl, (C3-C7) cycloalkyl, R25-(C1-C4) alkyl - and phenyl； R23 is selected from the series consisting of hydrogen and (C1-C4) alkyl； R24 is selected from the series consisting of halogen, (C1-C4) alkyl, cycloalkyl (C3-C7), HO-, (C1-C4) alkyl -O-, (C1-C4) alkyl -S (O) p -, F5S-, NC-, (C1-C4) alkyl -OC (O) -, -alkanediyl (C3-C5) -, -O-alkanediyl (C1-C4) -O- and -alkanediyl (C1- C4) -OC (O) -； R25 is selected from the series consisting of cycloalkyl (C3-C7), alkyl (C1-C4) -O- and alky
