PROBLEM TO BE SOLVED: To provide a novel agent which can effectively enhance the production of platelet derived growth factor-BB (PDGF-BB) contributing to the production promotion of mesenchymal stem cells or the stabilization of stem cells.SOLUTION: The invention provides a PDGF-BB production enhancer containing one or more, as an active ingredient, selected from Vaccinium vitis-idaea-derived material, Garcinia mangostana-derived material, Scutellaria baicalensis-derived material, inositol, and inositol phosphoric acid. Preferably inositol or inositol phosphoric acid is derived from rice bran, and yeast extract is also comprised while inositol or inositol phosphoric acid is comprised.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】間葉系幹細胞の産生促進や幹細胞の安定化に寄与する血小板由来成長因子-BB(PDGF-BB)の産生を有効に亢進し得る新規な剤の提供。【解決手段】コケモモ由来物、マンゴスチン由来物、オウゴン由来物、イノシトール及びイノシトール燐酸から選択される1又は2以上を有効成分として含んでなるPDGF-BB産生亢進剤。イノシトール又はイノシトール燐酸が米糠由来であることが好ましく、イノシトール又はイノシトール燐酸を含むと共に酵母エキスを更に含むPDGF-BB産生亢進剤。【選択図】なし