Anti-erbb3 antibodies and uses thereof

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专利权人:

REGENERON PHARMACEUTICALS INC.

发明人:

DUAN XUNBAO,DALY CHRISTOPHER,MACDONALD DOUGLAS

申请号：

NZ62343812

公开号：

NZ623438A

申请日:

2012.09.21

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is an isolated monoclonal antibody or antigen-binding fragment thereof that specifically binds ErbB3, wherein the antibody or antigen-binding fragment interacts with amino acids 345-367 of SEQ ID NO:498, amino acids 423-439 of SEQ ID NO:498； and amino acids 451-463 of SEQ ID NO:498, as determined by hydrogen/deuterium exchange, wherein the sequences are as defined in the complete specification. Also disclosed is use of the antibody for inhibiting or attenuating tumour growth.

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