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SCYTOVIRINS AND RELATED CONJUGATES, FUSION PROTEINS, NUCLEIC ACIDS, VECTORS, HOST CELLS, COMPOSITIONS, ANTIBODIES AND METHODS OF USING SCYTOVIRINS
专利权人:
发明人:
申请号:
EP03753112.6
公开号:
EP1515738B1
申请日:
2003.05.15
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
An isolated or purified antiviral protein consisting essentially of the amino acid sequence of SEQ ID NO: 1, an amino acid sequence that is about 90% or more identical to SEQ ID NO: 1, an amino acid sequence that is about 90% or more homologous to SEQ ID NO: 1, or an antiviral fragment of any of the foregoing a variant, fusion protein or conjugate thereof a composition comprising (i) at least one of the foregoing and (ii) a carrier, excipient or adjuvant an isolated or purified nucleic acid consisting essentially of a nucleotide sequence encoding the amino acid sequence of the aforementioned antiviral protein or antiviral fragment thereof, or a variant or fusion protein of either of the foregoing an isolated cell comprising an above-described isolated or purified nucleic acid a composition comprising (i) an above-described isolated or purified nucleic acid, and (ii) a carrier, excipient or adjuvant a method of inhibiting a viral infection of a host comprising administering a viral infection-inhibiting amount of at least one of an above-described antiviral protein or an antiviral fragment thereof, a variant or fusion protein of either of the foregoing, an above-described nucleic acid, or an isolated cell comprising an above­described nucleic acid a method of inhibiting a virus in a biological sample or in/on an inanimate object comprising contacting the biological sample or the inanimate object with a viral-inhibiting amount of at least one of an above-described antiviral protein or an antiviral fragment thereof, or a variant, fusion protein or conjugate of either of the foregoing, antibodies and composition thereof, and a method of inhibiting infection of a mammal with a virus comprising administering to the mammal an anti-scytovirin antibody in an amount sufficient to induce in the mammal an immune response to the virus.Une protéine antivirale isolée ou purifiée constituée essentiellement de la séquence dacide aminé SEQ ID NO: 1, une séquence dacide aminée moins à
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