Kiyoshi Kita,Ken Daniel Inaoka,Hiroyuki Saimoto,Masaichi Yamamoto
申请号：
US15181458
公开号：
US09737504B2
申请日:
2016.06.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I):(whereinX represents a halogen atom,R1 represents a hydrogen atom,R2 represents an alkyl group containing 1 to 7 carbon atoms,R3 represents —CHO, andR4 represents —CH2—CH═C(CH3)—R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)),an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.
