PARKS DANIEL,PLAYER MARK R,MEEGALLA SANATH,BRANUM SHAWN,CHEN JINSHENG,BALLENTINE SCOTT,PARSONS WILLIAM,CALVO RAUL
申请号：
NZ60199811
公开号：
NZ601998A
申请日:
2011.03.03
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
601988 Disclosed is directed to substituted aza-bicyclic imidazole derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold. Examples of compounds of formula (I) includes 2-(3-tert-butyl-4-chloro-1-methyl-1H-pyrazol-5-yl)-6-(2-chlorophenyl)-4-methoxy-3H-imidazo[4,5-c]pyridine； 2-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-6-(2-chloro-phenyl)-3Himidazo[4,5-c]pyridine hydrochloride and 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-6-(2-trifluoromethylphenyl)-3H-imidazo[4,5-c]pyridine-4-carbonitrile.
