THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH OFFICE OF TECHNOLOGY TRANSFER 6011
发明人:
PASTAN IRA H.,PASTAN Ira H.,WELDON JOHN,WELDON John,FITZGERALD DAVID,FITZGERALD David
申请号：
SI200831351
公开号：
SI2197903T1
申请日:
2008.09.04
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
