as represented by the Secretary of the Department of Health and Human Services;The Government of the United States of America
发明人:
Fitzgerald, David,Weldon, John,Pastan, Ira H.
申请号：
AU2008296194
公开号：
AU2008296194B2
申请日:
2008.09.04
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
