The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
发明人:
PASTAN, IRA H.,WELDON, JOHN,FITZGERALD, DAVID
申请号：
PL08799197
公开号：
PL2197903T3
申请日:
2008.09.04
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
