Compounds of formula I: wherein A is CH or N, B is CR or N； and D is CR； R represents hydrogen, OH or NH2； R1 and R2 are independent of each other Hydrogen, N (R3) 2, halogen, cyano, nitro, R4-C1-C4 alkyl, R4-C1-C4 halogenoalkyl, OH, R4-C1-C4 alkoxy, R4-C1-C4 halogenoalkoxy, SH , R4-C1-C4 alkylthio, R4-C1-C4 halogenoalkylthio； R3 independently represents hydrogen, R4-C1-C4 alkyl or R4-C1-C4 halogenoalkyl at each occurrence； R3a is Independently at each occurrence represents hydrogen or C1-C4 alkyl； R4 independently at each occurrence hydrogen, halogen, cyano, OH, SH, NH , NH (CH3) 2 or N (CH3) 2； X represents a group of formula -E- or -EF-, wherein E and F are different from each other and -C (R3a) 2- ,-(C = O)-, -NR3a- and -O-, and F is attached to Y, provided that when X represents -EF- Or one of F represents -C (R3a) 2- or-(C = O)-； Y is C1-C6 alkyl, monocyclic or bicyclic C3-C11 cycloalkyl, which may be partially unsaturated, Represents a group selected from monocyclic or bicyclic 3-11 membered heterocycloalkyl, monocyclic or bicyclic groups containing at least one aryl or heteroaryl ring, which may be partially unsaturated, wherein Said heterocycloalkyl group and at least one hetero Said group comprising a reel ring comprises one or more heteroatoms selected from nitrogen, oxygen and sulfur, and said group Y is unsubstituted or one or more substituents Including one or more nitrogen atoms substituted with and including the substituents, and Z is monocyclic or bicyclic containing at least one aryl or heteroaryl ring Represents a cyclic group, wherein the heteroaryl ring contains one or more heteroatoms selected from nitrogen, oxygen and sulfur, the aryl or heteroaryl group being unsubstituted or one or more Of the compound, which is a tautomer of the compound, a mixture of two tautomeric forms of the compound, and the compound A pharmaceutically acceptable salt thereof, a tautomer thereof or a mixture of the two tautomeric forms, preferably wherein X is — (C═O)
