Disclosed are compounds of formula (I) wherein A is CH or N B is CR or N and D is CR R represents hydrogen OH or NH R1 and R2 independently of each other represent hydrogen N(R3) halogen cyano nitro R4 C1 C4alkyl R4 C1 C4halogenoalkyl OH R4 C1 C4alkoxy R4 C1 C4halogenoalkoxy SH R4 C1 C4alkythio R4 C1 C4halogenoalkylthio R3 represents independently at each occurrence hydrogen R4 C1 C4alkyl or R4 C1 C4halogenoalkyl R3a represents independently at each occurrence hydrogen or C1 C4 alkyl R4 represents independently at each occurrence hydrogen halogen cyano OH SH NH NH(CH) or N(CH) X represents a group of formula E or E F wherein E and F are different from each other and represent a group selected from C(R3a)2 (C=O) NR3a and O and F is linked to Y with the proviso that if X represents E F one of E or F represents C(R3a) or (C=O) Y represents a group selected from C1 C6alkyl mono or bicyclic C3 C11cycloalkyl which may be partially unsaturated mono or bicyclic 3 to 11 membered heterocycloalkyl which may be partially unsaturated a mono or bicyclic group comprising at least one aryl or heteroaryl cycle wherein said heterocycloalkyl group and said group comprising at least one heteroaryl cycle comprise one or more heteroatoms selected from nitrogen oxygen and sulfur and said group Y is either unsubstituted or substituted by one or more substituents and comprises including its substituents one or more than one nitrogen atom having a lone electron pair and Z represents a mono or bicyclic group comprising at least one aryl or heteroaryl cycle said heteroaryl cycle comprising one or more heteroatoms selected from nitrogen oxygen and sulfur which aryl or heteroaryl group is unsubstituted or substituted by one or more substituents including tautomers of said compounds mixtures of two tautomeric forms of said compounds and pharmaceutically acceptable salts of said compounds tautomers thereof or mixtures of two tautomeric forms thereof preferably with the proviso
