A method for operating an imaging diagnostic device is proposed. Raw data is generated by the diagnostic device as a function of modality parameters while utilizing a contrast medium that is used in accordance with an injection protocol. Image data is generated from the raw data by image reconstruction as a function of reconstruction parameters. A quantitative measurement is performed in an image data evaluation by an analysis application. A subsidiary application automatically proposes a set of parameter values which is suited to the analysis application and relates to the injection protocol utilizing stored comparison data.