CLARIDGE, STEPHEN WILLIAM,VAISBURG, ARKADII,UNO, TETSUYUKI,RAEPPEL, STÉPHANE,ISAKOVIC, LJUBOMIR,MANNION, MICHAEL,SAAVEDRA, OSCAR MARIO,GAUDETTE, FRÉDÉRIC,ZHAN, LIJIE,ZHOU, NANCY Z.,RAEPPEL, FRANCK,DÉZ
申请号：
MYPI 2010000797
公开号：
MY156536A
申请日:
2008.08.28
申请国别(地区):
MY
年份:
2016
代理人:
摘要：
THE INVENTION RELATES TO COMPOUNDS OF FORMULA (I) AND THEIR USE FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY IN FORMULA (I), THE GROUP M IS THIENO[3,2,B]PYRIDINYL AS SHOWN, AND THE GROUP D IS A RING OR RING SYSTEM, AND THE GROUPS Z, AR, AND G ARE AS DEFINED HEREIN. THE INVENTION RELATES PARTICULARLY TO COMPOUNDS THAT INHIBIT THE PROTEIN TYROSINE KINASE ACTIVITY OF GROWTH FACTOR RECEPTORS, RESULTING IN THE INHIBITION OF RECEPTOR SIGNALLING, FOR EXAMPLE, THE INHIBITION OF VEGF RECEPTOR SIGNALLING AND HGF RECEPTOR SIGNALLING THE INVENTION ALSO PROVIDES COMPOSITIONS AND METHODS FOR TREATING CELL PROLIFERATIVE DISEASES AND CONDITIONS, SUCH AS CANCER, AND FOR TREATING OPHTHALMIC DISEASES, INCLUDING AGE-RELATED MACULAR DEGENERATION (AMD) AND DIABETIC RETINOPATHY (DR).
