Raeppel, Stephane,Isakovic, Ljubomir,Zhou, Nancy Z.,Saavedra, Oscar Mario,Raeppel, Franck,Claridge, Stephen William,Uno, Tetsuyuki,Gaudette, Frederic,Deziel, Robert,Zhan, Lijie,Mannion, Michael,Vaisbu
申请号：
AU2008293038
公开号：
AU2008293038B2
申请日:
2008.08.28
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention relates to compounds of Formula (I) and their use for inhibitingprotein tyrosine kinase activity In Formula (I), the group M is thieno[3,2,b]pyridinylas shown, and the group D is a ring or ring system, and the groups Z, Ar, and G are asdefined herein The invention relates particularly to compounds that inhibitthe protein tyrosine kinase activity of growth factor receptors, resultingin the inhibition of receptor signalling, for example, the inhibition of VEGFreceptor signalling and HGF receptor signalling The invention also providescompositions and methods for treating cell proliferative diseases and conditions,such as cancer, and for treating ophthalmic diseases, including age-relatedmacular degeneration (AMD) and diabetic retinopathy (DR).
