ZHAN LIJIE,VAISBURG ARKADII,UNO TETSUYUKI,DEZIEL ROBERT,ISAKOVIC LJUBOMIR,MANNION MICHAEL,GAUDETTE FREDERIC,CLARIDGE STEPHEN WILLIAM,RAEPPEL STEPHENE,SAAVEDRA OSCAR MARIO,ZHOU NANCY Z,RAEPPEL FRANCK
申请号：
IN805/KOLNP/2010
公开号：
IN281974B
申请日:
2010.03.03
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention relates to compounds of Formula (I) and their use for inhibiting protein tyrosine kinase activity. In Formula (I), the group M is thieno[3,2,b]pyridinyl as shown, and the group D is a ring or ring system, and the groups Z, Ar, and G are as defined herein. The invention relates particularly to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signalling, for example, the inhibition of VEGF receptor signalling and HGF receptor signalling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions, such as cancer, and for treating ophthalmic diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR).
