Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.本揭示內容揭示一免疫組合物,包含一可內含於A型流行性感冒病毒中的血球凝集素變異體及/或神經胺酸酶變異體,以及其引發對抗A型流行性感冒病毒之免疫反應的用途。