LIANG, SHU-MEI,杨淑美,楊淑美,LIANG, CHI MING,梁启铭,梁啟銘,CHEN, YEN PO,陈彦柏,陳彥柏,HUANG, CHUN YUNG,黄俊勇,黃俊勇
申请号：
TW098108326
公开号：
TWI392739B
申请日:
2009.03.13
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
A method is for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a an isolated and/or purified globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, and applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced fibrillar protein formation from globular protein. A method for producing a vaccine adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.一種用來改變球狀蛋白質結構為纖維狀蛋白質結構的方法。此方法包括提供一分離或純化的球狀蛋白質、在含有該球狀蛋白質的溶液內加入皂化劑、再將含有該蛋白質的溶液通過分子分級管柱,孔洞大小允許分離至少為70 kDa分子量蛋白質的分級管柱,以利用管柱來促成纖維狀蛋白質之形成,並同時利用含有少量皂化劑的溶液及管柱來分離纖維狀蛋白質。一種用來生產疫苗佐劑的方法,此方法包括提供一蛋白質,將此蛋白質改變為纖維狀結構。
