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Intermediate indole (aza) derivative substituted at position 5
专利权人:
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.
发明人:
ALISI, MARIA ALESSANDRA,FURLOTTI, GUIDO,CAZZOLLA, NICOLA,MAUGERI, CATERINA,DRAGONE, PATRIZIA,GAROFALO, BARBARA,COLETTA, ISABELLA,MANGANO, GIORGINA,GARRONE, BEATRICE
申请号:
ES11194457
公开号:
ES2523167T3
申请日:
2008.12.16
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Intermediate compound of formula (III): ** Formula ** in which G1, G2 and G3, which may be identical or different, are a nitrogen atom or a CH group; R1 is a (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) -ORI, (CH2) nCONRIIRIII, (CH2) nCORI, (CH2) nCOORII, (CH2) nOCORI, SO2RI, ( CH2) nNRIISO2RI, (CH2) nSO2RI, optionally substituted with 1 to 3 hydroxyl groups, in which n is an integer from 1 to 6, RI is a (C1-C3) alkyl or (C1-C3) -OH alkyl group, and RII and RIII, which may be identical or different, are a hydrogen atom or a (C1-C3) alkyl group; W is a σ bond, or a (C1-C6) alkyl, (C2-C6) alkenyl, O-(C1-C6) alkyl, O-C2-C6 alkenyl, (CH2) pCO (CH2) qo ( CH2) pC (OH) (CH2) q, in which pyq, which may be identical or different, are an integer from 0 to 3; and R2 is a phenyl or pyridine group, optionally substituted with 1 to 3 substituents, which may be identical or different, represented by an LM group, in which L is a σ bond, or a (C1-C6) alkyl group, (C2-C6) alkenyl, (C2-C6) alkynyl, O-(C1-C6) alkyl, O-C2-C6 alkenyl, O-C2-C6 alkynyl, and M is a hydrogen atom of halogen, or a group OH, CF3, NO2, COORII, SO2NHRII, CH2CONRIIRIII, NRIIRIII, SO2RIV, NHSO2RIV, PORIVRV or OPORIVRV, in which RII and RIII, which may be identical or different, have the previous meaning, and RIV and RV , which may be identical or different, are a (C1-C3) alkyl group, provided that when G1, G2 and G3 are all a CH group, R1 is a (C1-C6) alkyl or cycloalkyl (C3-C7) group, optionally substituted with 1 to 3 hydroxyl groups, W is a σ bond, and the bond between carbon atoms in position 2 and 3 is a double bond, R2 is not a phenyl or pyridine group, optionally substituted with 1 to 3 substituent s, which may be identical or different, selected from halogen, (C1-C6) alkyl optionally substituted with a hydroxyl, trifluoromethyl, nitro, amino, di ((C1-C3) alkyl) amino, hydroxyl, (C1-) alkoxy group C3), COOH, COORII, SO2CH3, SO2NHCH3, NHSO2CH3, PORIVRV, OPORIVRV, alkyl (C1-C6) -COOH and alkenyl (C2-C6) -COOH;
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