The NS5A HCV of the protein inhibitor of pot genome encoding, pharmaceutical composition, the synthesis of the intermediate for inhibitor, and its synthesis and application method
Aleksandr Vasilevich Ivashchenko (US),Александр Васильевич Иващенко (US),Mitkin Oleg Dmitrievich (RU),Митькин Олег Дмитриевич (RU)
申请号：
RU2017120825
公开号：
RU0002669919C1
申请日:
2016.06.24
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
Compound shown in formula 1:Or its pharmaceutically acceptable salt, hydrate, crystal form or its stereoisomer, in formula: R1 is hydrogen, tertbutyloxycarbonyl,Here R11 is the C1-C6 alkyl optionally replaced, the C3-C6 naphthenic base optionally replaced, the C1-C6 alkoxies optionally replaced, arrow (position) ← expression substituent group connection R2 is hydrogen, halogen or C1-C4alkyl R3 is the aryl optionally replaced, the aryloxy group optionally replaced, the arylsulfanyl optionally replaced, the arylamino optionally replaced or the nitrogenous heteroaryl optionally replacedHere R41 is the C1-C6 alkyl optionally replaced, the C3-C6 naphthenic base optionally replaced, the C1-C6 alkoxies optionally replaced X buta-1,3-diynylene or Isosorbide-5-Nitrae-phenylene Arrow indicates the connection of (position) ← substituent group.
