KRETZSCHMAR GERHARD,KRAFT VOLKER,OLPP THOMAS,ROSSEN KAI
申请号：
ZA201107655
公开号：
ZA201107655B
申请日:
2011.10.19
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
