KAI ROSSEN,VOLKER KRAFT,GERHARD KRETZSCHMAR,THOMAS OLPP
申请号：
PT10724024
公开号：
PT2435398E
申请日:
2010.05.26
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
