GERHARD KRETZSCHMAR,KAI ROSSEN,THOMAS OLPP,VOLKER KRAFT
申请号：
BRPI1014547
公开号：
BRPI1014547A2
申请日:
2010.05.26
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
