Sterol derivatives and their use for treating diseases associated with transformed astrocytes or for treating malignant blood diseases

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专利权人:

ベータ・イノブ

发明人:

クラリオン，リュドビク,メルセル，マルセル,プティット，ディディエ,クラリオン,リュドビク,メルセル,マルセル,プティット,ディディエ

申请号：

JP2015510925

公开号：

JP6270823B2

申请日:

2013.05.07

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n； R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2)； n : 1-3； R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3； R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6； R, R4 : H, 1-12C alkyl or optionally substituted aryl； R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR)； R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR)； B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR)； R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8； and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I)； and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.

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