STEROL DERIVATIVES AND USE THEREOF FOR TREATING DISEASES INVOLVING TRANSFORMED ASTROCYTE CELLS OR FOR TREATING MALIGNANT HAEMOPATHIES

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专利权人:

BETA INNOV

发明人:

DIDIER PETITE,LUDOVIC CLARION,MARCEL MERSEL

申请号：

PT13729470

公开号：

PT2847204T

申请日:

2013.05.07

申请国别(地区):

PT

年份:

2018

代理人:

摘要：

Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2) n : 1-3 R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3 R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6 R, R4 : H, 1-12C alkyl or optionally substituted aryl R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR) R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR) B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR) R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8 and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I) and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.

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