STEROL DERIVATIVES AND USE THEREOF FOR TREATING DISEASES INVOLVING TRANSFORMED ASTROCYTE CELLS OR FOR TREATING MALIGNANT HAEMOPATHIES

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专利权人:

베타 인노브

发明人:

끌레히옹, 루도비크,메르젤, 마르셸,쁘띠, 디디에

申请号：

KR1020147034290

公开号：

KR1020150013254A

申请日:

2013.05.07

申请国别(地区):

KR

年份:

2015

代理人:

摘要：

Sterol derivatives of (I) are new. Sterol derivatives of formula (I) are new. A1 : -(R1) n； R1 : amino acid residue bonded to its C-terminal end (optionally substituted by -C-(O)-R2)； n : 1-3； R2 : mono- or multi- cyclic 6-14C arylalkyl or mono- or multi- cyclic 5-14C heteroarylalkyl including heteroatoms, mono- or multi- cyclic 6-14C arylalkyloxy or mono- or multi- cyclic 5-14C heteroarylalkyloxy including heteroatoms, -C-(O)-NH-R3 or -C-(S)-NH-R3； R3 : H, linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR), aryl (optionally substituted by OR, NRR4, NHR or SR), acyl, formyl, sulfonyl, sulfinyl, silyl (optionally substituted by mono- or multi- cyclic 6-14C-aryl or linear or branched 1-6C alkyl), allyl, sugar, -C-(O)-OR5, amide, thioamide, sulfonamide or -C(O)-R6； R, R4 : H, 1-12C alkyl or optionally substituted aryl； R5 : linear or branched 1-12C-alkyl (optionally substituted by OR, NRR4, NHR or SR)； R6 : saturated 5-14C heterocycle comprising 1 or 2 heteroatoms (optionally substituted by linear or branched 1-6C-alkyl or OR, NRR4, NHR or SR)； B1 : -C(O)-R7 or aryl (optionally substituted by OR, NRR4, NHR or SR)； R7 : H, 1-12C-alkyl, preferably linear or branched 1-6C-alkyl (optionally substituted by OR, NRR4, NHR or SR) or OR8； and R8 : 1-12C-alkyl, preferably linear or branched 1-6C-alkyl. Independent claims are included for: (1) preparing (I)； and (2) a composition comprising (I) a carrier. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.본 발명은 신규 스테롤 유도체, 그의 제조 방법, 그를 함유하는 제약 조성물, 및 형질전환된 성상세포와 관련된 질환 또는 악성 혈액병증을 치료하기 위한 그의 용도에 관한 것이다. 본 발명은 특히 다형성 교모세포종뿐만 아니라, 다른 암, 예컨대 림프종, 신경모세포종 및 흑색종의 치료에 관한 것이다.

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