INHIBITING THE INTEGRATION OF RETROVIRUS DNA INTO HOST CELL DNA BY INHIBITING INTEGRASE REACHING DIMER FORMATION

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专利权人:

发明人:

Anna Marie Skalka,Mark Andrake,Ravi Shankar Bojja

申请号：

US13923494

公开号：

US20130280271A1

申请日:

2013.06.21

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Methods to inhibit the formation of retrovirus integrase reaching dimers, to dissociate retrovirus integrase reaching dimers, and to stabilize retrovirus integrase reaching dimers in a conformation in which retrovirus DNA-to host cell DNA integration activity of the integrase is inhibited are provided. Methods for treating a retrovirus infection, which target retrovirus integrase reaching dimer formation and/or stability are also provided.

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