CHEMOTHERAPEUTIC INTRODUCTION OF EGR-1 PROMOTER ACTIVITY IN GENE THERAPY

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专利权人:

DANA-FARBER CANCER INSTITUTE;THE UNIVERSITY OF CHICAGO

发明人:

WEICHSELBAUM, RALPH,KUFE, DONALD,GUPTA, VINAY,MAUCERI, HELEN,PARK, JAMES,POSNER, MITCHELL

申请号：

AT02731264

公开号：

AT541937T

申请日:

2002.04.05

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

The present invention provides for improved therapeutic regimens for treating benign hyperproliferative diseases and cancers. The Egr-1 promoter, long known to be radiation-responsive, has now been shown to be inducible for DNA damaging chemical agents, many of which themselves are used in therapies. Thus, the present invention provides for the advantageous combination of a DNA damaging chemical and an expression vector containing a therapeutic gene driven by the Egr-1 promoter.

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