A method is provided to prevent and to treat alopecia by using Calcium Channel Blockers (CCB), Angiotensin-Converting Enzyme (ACE) Inhibitors, or Angiotensin Receptor Blockers (ARB), and more particularly, to a method to prevent and treat alopecia by using Calcium Channel Blockers, Angiotensin-Converting Enzyme Inhibitors, or Angiotensin Receptor Blockers that are not taken orally, but administered through the skin into the scalp space to form contact with the scalp skin where hair loss is present to treat and to heal hair loss.